Project Fizzyo!

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About Fizzyo

Cystic Fibrosis is a chronic, life-limiting condition affecting sufferers from birth. Approximately 1 in 2500 babies are born with CF.

With improved prevention and treatment life expectancy for patients has slowly increased and currently stands at an average of 41 years of age.

Project Fizzyo is about trying to improve physiotherapy care for children with Cystic Fibrosis. Airway clearance techniques (ACTs), physical activity and exercise can mitigate the progression of Cystic Fibrosis (CF) lung disease, but routine physiotherapy treatments are burdensome and adherence is low. Traditional research methods (RCTs) have failed to produce credible evidence to guide practice, partly because ‘blinding’ isn’t possible and patient preference can confound results.

We have worked with engineers and designers and UCL computer science students through the Industry Exchange Network (IXN) to develop electronically chipped ACT devices and wearable activity trackers to facilitate automatic data transmission from the homes of children with CF to the clinicians and researchers caring for them. Industry partners (Microsoft) and UCL computer science experts and students have also helped us develop computer games driven by breathing through an ACT device (to enhance treatment enjoyment and adherence).

The project will use this technology for passive remote capture and transmission of longitudinal data during ACTs, physical activity and exercise daily in 160 children over 18 months. A data scientist will use this data, reconciled with individual demographic and longitudinal clinical records, to identify positive and negative clinical outcome predictors. Computer gaming will be introduced and removed (interrupted time series design) to evaluate the effect of gaming on ACT adherence and clinical outcomes during the study.

This exciting remote monitoring platform has the potential in future to guide personalised physiotherapy prescription based on individual treatment responses, generate accurate, sustainable population-based physiotherapy registry data, and provide a template for remote monitoring of other interventions in CF across the NHS.

The Fizzyo device is a wireless sensor that connects to existing CF Physiotherapy equipment, turning breaths into controls for video games.

Winner of Tech for Good Ability.Net Digital Health Award 2017.

CF Trust

Ability.Net Awards Winner

Unity3d Framework

Start Hacking! There’s a lot you can do with the resources below. There are some getting started guides for starting on your Fizzyo game development Journey.
Project Fizzyo Unity3d Resources
Understand how to get started with the Project Fizzyo Unity3d Framework Project Fizzyo.


Innovative big data analysis methods will be used to address the primary research questions below:

  • What is the proportionate impact of adherence with prescribed ACTs and exercise on clinical outcomes in children with CF?
  • What is the specific impact of feedback or gaming technology during ACTs and exercise on adherence over time and the impact of this adherence on clinical outcomes?
  • Which particular ACT technique is associated with the best clinical outcomes in children with CF, aged 6-16 years? (and at what ages or stages of disease are different ACTs most effective)
  • What is the minimum effective dose of ACTs, physical activity or exercise and the proportionate benefits of each to sustain optimal lung function and exercise capacity, and reduce hospital admissions?
  • Can any improvements in adherence to ACTs from feedback or computer gaming be sustained over long periods of time?
  • Can remote monitoring and big data analysis help identify sensitive composite outcome measures for children with mild signs and symptoms.

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    “Technology such as this is not currently available and we believe has the potential to really change the way these children are cared for in the NHS.” Professor Eleanor Main, University College London, Physiotherapy.

    Great Ormond Street Institute of Child Health

    Fizzyo Team

    Professor Eleanor Main, University College London, Professor Physiotherapy

    Timur Kuzhagaliyev, University College London, UCL Student Team Lead,

    Dr Yun Fu, University College London, UG Student Supervisor

    Dr Harriet Shannon, University College London, PhD Supervisor

    Emma Raywood, University College London, PhD Fellow

    Sarah Rand, University College London, Physiotherapist

    Helen Douglas, University College London, Physiotherapist

    Kunal Kapoor, University College London, Data Science Machine Learning

    Dr Colin Wallis, University College London, GOSH CF Consultant

    Rachel O'Connor, Royal London Hospital, Physiotherapist

    Nicky Murray, Royal Brompton Hospital, Physiotherapist

    Haiyan Zhang, Microsoft Research, Cambridge, Director of Innovation

    Greg Saul, Microsoft Research, Cambridge, Snr. Creative Design Technologist

    Lee Stott, Academic Engagements, Microsoft UK

    Nicolas Villar, Microsoft Research, Cambridge, Senior Researcher

    Anita Ramanan, Microsoft, Software Engineer

    Mason Cusack, Microsoft, Software Engineer

    Jude Pullen, Maker

    Ryan White, Maker


    News and Updates

    5 July 2018

    Project Fizzyo reaching milestone for Patient Trial Go Live

    12 July 2017

    Tech4Good Winners 2017

    Project Fizzyo Announced as Winner of AbilityNet Tech4Good Award 2017 - Digital Health Award Both of Vicky Coxhead’s sons have Cystic Fibrosis and because of this they have to do regular physio to keep infections at bay. She applied to feature on a a new BBC2 documentary asking for families with a problems to get in touchand was introduced to Haiyan Zhang, who volunteered to help. Haiyan works as Innovation Director at Microsoft Research in Cambridge. She enlisted the help of Creative Technologist Greg Saul to create a device that could take the boys’ breaths and turn them into controls for a videogame. Together, with Lee Stott at Microsoft UK, they organised hackathons where volunteer designers and engineers from across the UK came along to make new video game experiences for the Coxhead boys. Tech4Good 2017 Winners

    19 June 2017

    Tech4Good Shortlisted Finalist 2017

    We are proud to announce the that Fizzyo has been shortlisted as a finalists for this year’s AbilityNet Tech4Good Awards 2017 – 32 amazing businesses, charities and individuals who use digital technology to make the world a better place. They have been shortlisted in eight categories but you can vote for your favourite to win the Tech4Good People’s Award, which will be announced at our awards ceremony on 11 July. Tech4Good 2017 Finalist Shortlist

    1st April 2017

    Understand Game Play and how patients undertake Physio during a gaming session - Example of the Qubi Game Play Project Fizzyo.

    Understand how to get started with the Project Fizzyo Project Fizzyo Source Control.

    21st March 2017

    D&AD Impact & Microsoft Present Innovative Technology For Good - Project Fizzyo

    TOWN HALL SERIES: D&AD Impact & Microsoft Present Innovative Technology For Good from AdvertisingWeek on Vimeo.

    21 Feb 2017

    How IOT and data is changing lives